New medications are in development and may provide further treatment to consider in drug-resistant epilepsy the sequelae to acute encephalopathy or encephalitis. There has been a long interest in the possible benefits of cannabidiol in epilepsy, with many anecdotal reports suggesting not only seizure control but also improved alertness and quality of life.22 Cannabidiol as produced by GW Pharma, almost pure cannabidiol with insignificant tetrahydrocannabidiol (THC), has been evaluated as an add-on therapy in Dravet syndrome and Lennox-Gastaut syndrome, benefits seen over placebo in a randomized controlled trial reported most recently in Dravet syndrome.23 The mechanism of action and consequently specificity to this syndrome remain unclear; therefore possible utilization in other drug-resistant epilepsies should be considered. However, a definite interaction with clobazam has been documented, with a tendency to raised levels of the clobazam metabolite, norclobazam in children taking cannabidiol concomitantly.24 Fenfluramine is a further agent undergoing trial in Dravet syndrome; definitive results are awaited. Open label use has suggested an encouraging response in major motor seizures.25,26 Cardiac side effects, as emerged with previous use, are being evaluated although the dose currently being utilized is far lower than that associated with cardiac side effects with previous use.
In fact, the U.S. Food and Drug Administration (FDA) approved Epidiolex (a drug made with a purified form of CBD oil) in June 2018 for the treatment of seizures associated with two rare and severe forms of epilepsy in patients 2 years of age and older. These two epilepsy forms are known as Lennox-Gastaut syndrome and Dravet syndrome. Epidiolex is the first FDA-approved drug that contains a purified drug substance derived from marijuana.
CBD interacts with the body through the endogenous cannabinoid system (ECS) or endocannabinoid system. First discovered in the late 1980’s, the endocannabinoid system regulates the body’s homeostasis, or general state of balance, impacting such functions as mood, sleep, appetite, hormone regulation, and pain and immune response. Like an acrobat on a highwire, as the environment around us impacts our normal balance, the endocannabinoid system “corrects” by mediating our body’s reaction to keep us level.
Butter substitutes like margarine, smart balance and earth balance are mostly a mix of canola and soybean oils. You can revisit #2 & #3 of this list to read more details about why these oils are not healthy, but basically, soybean oil is too high in omega-6 fatty acids which can lead to inflammation and other diseases. Canola oil is highly processed and treated with chemical deodorizers and solvents.
The CBD oil needs to be taken twice a day everyday. The dosage depends on symptoms and it takes 30 days to awken your natural cannabis system after you begin taking the oil. I personally use Hemp works CBD oil in the 750 strength and only need 5 drops sublingual 2 times daily and results are many. Problem with oil and alz.patients is getting them to hold oil under tongue for 60 seconds. We have just began to get my dad on it. He too is in a nursing home in the state of florida and they cannot deny him any medication my mom has requested that he receive. If she is not their they are supposed to administer and she will call them to make sure he gets it. He is not 30 days into dosing yet so I don't have any results to speak of. I do know that since he has started he has had no more bladder infection and has not fallen in 3 weeks. That's a record for him so we will continue to monitor. Best of luck to you and a lot is going to depend on the state your mom is in and what the state laws are concerning her rights or the rights of whom has her medical power of attorney
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Cutting-edge science has shown that the endocannabinoid system is dysregulated in nearly all pathological conditions. Thus, it stands to reason that “modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans,” as Pal Pacher and George Kunos, scientists with the U.S. National Institutes of Health (NIH), suggested in a 2014 publication.