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One year before the molecular characterization of THC, another abundant cannabis component, cannabidiol (CBD), had already been identified (Michoulam and Shvo, 1963), whereas other chemically related terpenophenolic compounds, including cannabichromene (CBC) and cannabigerol (CBG), were isolated from Cannabis sativa soon thereafter (Gaoni and Mechoulam, 1964b; Gaoni and Mechoulam, 1966). When it became clear that these natural products are nearly unique to the cannabis plant, or maybe simply because they were first identified from this source, these compounds were collectively named “cannabinoids.” Thus, the name “cannabinoid” indicates any secondary metabolite from various strains of cannabis with biogenetic origin from a terpene, normally geranyl pyrophosphate, and a phenol, i.e., olivetol or olivetolic acid. It is now established that cannabinoids are produced by the plant flowers as their corresponding carboxylic acids, which are then decarboxylated following heating or desiccation. Interestingly, a compound similar to CBG acid, but clearly not directly derived from olivetol, was recently isolated from South African plants of the Helichrysum genus (Lourens et al., 2008). Thus, cannabinoids might not be unique to the cannabis plant, although their biosynthesis in other plants might follow different routes. Furthermore, of all the natural cannabinoids that were initially tested, THC was shown to be the only one responsible for the “recreational” properties induced by the smoking of marijuana in humans. These properties can be described as generally mood and sensory altering effects leading to, among others, euphoria and sedation (Panagis et al., 2008). Later, a definition of THC-like activity was given as the ensemble of “central” pharmacological effects that THC induces in non-human primates, dogs (ataxia), and rodents. In mice, it was proposed that the concomitant induction of: (1) immobility in a square box, (2) catalepsy on a ring, (3) analgesia in the hot plate or tail flick tests, and (4) hypothermia, known as the “tetrad” of tests for “cannabimimetic” activity, would be a good predictor of THC-like pharmacological activity (Martin et al., 1991).
Like most herbs, cannabis does have some antimicrobial and immune-boosting properties, but it is not as strong an antimicrobial as many other herbs. There are many better herbal choices for overcoming chronic Lyme disease and similar conditions related to chronic infections with stealth microbes such as fibromyalgia and chronic fatigue syndrome. (Top ones include andrographis, berberine, cat’s claw, Japanese knotweed, sarsaparilla, and garlic.)
One population-based case-control study found that in terms of lung cancer risk, smoking one joint of cannabis was similar to smoking 20 tobacco cigarettes. In addition to the negative physical effects, which also include decreased immune function, higher rates of irregular heartbeat, and stroke, cannabis smoking has been linked to mental conditions, including depression, bipolar disorder, and psychosis.
It’s also one of the strongest and most concentrated CBD products on the market today. With a grain-of-rice-sized recommended serving taken orally twice a day, its potent punch acts quickly—in just ten to fifteen minutes—to provide powerful relief. Furthermore, it offers terrific value for your money, boasting more CBD per dollar than many other CBD products.