Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.
I started with the 500mg tincture to test the product and now I purchase the 3000mg. Its good value and really helps my daily anxiety. The 500mg I had to take every 2 hours but the 3000mg is stronger and lasts me 4-5 hours. I never leave reviews but promised one of the customer service reps I would based on how helpful they were. Company seems legit.

Cannabinoids are psychoactive compounds with medicinal properties. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most studied cannabinoids. CBD has substantially less psychoactive properties than THC. Synthetic cannabinoids (e.g., dronabinol) are closely related to THC. Based on systematic reviews, the evidence published to date indicates that oral cannabis extract is clearly effective, and THC is most likely effective in reducing pain (excluding central neuropathic pain) and spasticity symptoms. They are probably not effective in improving tremor or signs of spasticity.82 There is insufficient evidence for effects on urge incontinence or bladder symptoms.82 Sativex oromucosal spray (unavailable in the US) is probably effective for spasticity symptoms, pain, and urinary frequency, and probably ineffective for signs of spasticity, incontinence episodes, and tremor.82 There is insufficient evidence for these outcomes with inhaled cannabis.82 Prior to recommending this therapy, physicians should counsel patients about the potential legal issues and unwanted side effects.


Thank you. I am 81 and started the CBD drops night and morning. I sleep better and no longer suffer the excruciating pain from diverticulitis. I saw somewhere that for my asthma I need the THC so got some (totally illegal here in South Africa). I think it is helping. The diagnosis of COPD was made some years ago and as a health psychologist I do all I can to remain healthy for my 97th birthday!! (Both my grandmother and greatgrandmother did so I believe I will too).
Sleep disturbance is a common side-effect of marijuana withdrawal. Among 1735 frequent users of marijuana (>21 occasions in a single year), 235 (13.5%) reported difficulty sleeping during withdrawal (Wiesbeck et al., 1996). Difficulty falling asleep and decreased SWS% have been documented during the first two nights (Freemon, 1982) of withdrawal. While acute exposure to low doses (2 mg) of THC decreases REM sleep (Pivik et al., 1972), there is no REM sleep rebound during the withdrawal period (Freemon, 1974). Higher doses (70–210 mg), on the other hand, resulted in REM sleep rebound during withdrawal (Feinberg et al., 1976). Daytime consequences are reported following higher doses of THC, including mild hangovers (Cousens and Dimascio, 1973), increased sleepiness, mood changes, and impaired memory (Nicholson et al., 2004). Objective methods of assessing sleepiness, such as the MSLT, have not been utilized to assess daytime consequences of THC.
Given CBD’s reputation as a popular, artisanal remedy, one would think that Epidiolex would command a lot of “off label” attention. After all, physicians often prescribe pharmaceuticals off label to treat conditions that were not the actual focus of clinical trials. But the costly price tag for Epidiolex (more than $30,000 annually) precludes off label prescribing as well as affordable access for tens of millions of Americans without health insurance.
A JAMA study published by the American Medical Association in November 2017 documents the mislabeling of some CBD products. The study found that 69 percent of the products examined contained different levels of CBD than what was identified on the label. THC was detected in 21 percent of the products tested, and the THC content in some of those products was enough to produce intoxication or impairment.
Almost completely eradicated my anxiety, which had been a severe hinderance to my life. The THC Free aspect is great for my line of work, and its no joke - I passed my last drug test. I ended up with the 1000mg strength, working my way up to 1mL from 0.5mL and 0.75mL. Also, Customer Service, when I was initially doing research, was top notch (I havent had to contact them since, but Im sure theyre still great lol).
A major goal of acute stroke care entails salvaging the penumbra and extra-penumbral regions of brain by preventing further growth of the infarct zone. Necrosis and apoptosis within the stroke core lead to free radical formation, glutamate release, and an inflammatory cascade leading to accumulation of intracellular calcium and cell death [12]. Endocannabinoids accumulate in ischemic tissue with CB 1 receptor (CB1 receptor) activation resulting in neuroprotective mechanisms including inhibition of glutamate release, decrease in intracellular calcium, hypothermia, decreased reactive oxygen species, and expression of brain-derived neurotrophic factor (BDNF). CB 2 receptor (CB2 receptor) activation leads to a decrease of leukocyte adhesion and cytokine release [12].
To date, 23 states and the District of Columbia have passed laws allowing marijuana to be used for a variety of medical conditions. Fifteen additional states have enacted laws intended to allow access to CBD oil and/or high-CBD strains of marijuana. Interest in the potential therapeutic effects of CBD has been growing rapidly, partially in response to media attention surrounding the use of CBD oil in young children with intractable seizure disorders including Dravet syndrome and Lennox-Gastaut syndrome. While there are promising preliminary data, the scientific literature is currently insufficient to either prove or disprove the efficacy and safety of CBD in patients with epilepsy.i and further clinical evaluation is warranted. In addition to epilepsy, the therapeutic potential of CBD is currently being explored for a number of indications including anxiety disorders, substance use disorders, schizophrenia, cancer, pain, inflammatory diseases and others. My testimony will provide an overview of what the science tells us about the therapeutic potential of CBD and of the ongoing research supported by NIH in this area.
After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.

Many people want to use CBD oil for anxiety and depression, and it’s easy to understand why. After all, one of the core benefits of CBD is its ability to produce an effect that brings calm to both a restless and worried mind and a tired, weary body, without any harmful psychoactive side effects. The products are also very simple to use and boast a number of natural, organic ingredients.
After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.
Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck
I have dealt with overall muscle pain for several years and was finally diagnosed with fibromyalgia 6 months ago. Due to stomach issues, I am no longer able to take NSAIDs, and I don’t want to start down the opioid trail, so I’ve been pretty miserable. Most days I felt like I’d been hit by a truck, and by the end of a work day, I was done. Many evenings I had to use a foam roller on my neck, back, and legs before I could even think of going to bed, and just trying to sit and relax was sometimes impossible. My husband did a lot of research on CBD oil, and Medterra seemed to be a solid company with a good following. He got me a bottle of the 1,000mg tincture, and I “front-loaded” with two doses a day for the first 5 days, then went down to one 1ml dose each morning. Even though we were on a lake vacation and I was climbing in and out of the boat and bouncing around the lake, I noticed that the pain and achiness in my arms and legs was gone within the first couple of days. After a couple more days, I realized that the pain and tightness in my upper back/neck were nearly gone as well. I’m starting to get my “old” energy back, and I can focus on doing what I want to do without the pain constantly interfering. My next order will be for the 3,000mg tincture... I want to play with the dosing a bit and see if I can get some relief with lower back pain (unrelated to the fibro). If you’re dealing with muscle pain, I highly recommend giving Medterra CBD oil a try.
My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary

Cbd Oil


Oils labeled as "partially hydrogenated." Most partially hydrogenated oils are made from vegetable oils like soybean or cottonseed, according to the Center for Science in the Public Interest. Partially hydrogenated oils are trans fats — fats that the FDA claims have been shown to increase your risk for heart disease. Recently, the FDA ruled that manufacturers must remove all trans fats from their products by 2018. You should remove partially hydrogenated oils from your diet, too, Warren says.
The smoke point is the temperature that causes oil to start smoking, which produces toxic fumes and harmful free radicals (the stuff we’re trying to avoid). Because of their chemical makeup, different oils have different smoke points. So some oils are better suited for cooking at higher temperatures than others. A good rule of thumb is that the more refined the oil, the higher the smoke point. Vegetable, peanut and sesame oils have the highest smoke points. Note: Smoke point relates only to fresh oil; oil that is used for cooking and then strained and re-used loses its integrity.
Discontinue use and consult a medical doctor immediately if you experience unusual symptoms. Consult a medical doctor before use if you have been treated for, or diagnosed with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Consult a medical doctor before starting any diet or exercise program. Improper use of this product will not improve results and is not advised. Use only as directed.
Canola oil is valuable for its neutral flavor and high smoke point, ultimately reducing the likelihood of harsh compound creation at high heat. Though it contains lesser amounts of antioxidants compared to olive oil, it contains alpha-linolenic acid, a kind of omega-3 fatty acid. Alpha-linolenic acid may reduce inflammation associated to arthritis, inflammatory bowel disease, and cardiovascular disorders.

despite what you say on canola and soybean oil being healthy i strongly disagree with you after my research on both of them. Canola oil is not really a natural oil it is manufactured oil from rapeseed. “Canola oil is made with a highly unnatural processing method that involves high heat, deodorization and the toxic solvent hexane. Significant amounts of trans fats are formed during this process.” also “One study analyzed canola and soybean oils found on store shelves in the U.S. They found that 0.56% to 4.2% of the fatty acids in them were toxic trans fats “


Butter substitutes like margarine, smart balance and earth balance are mostly a mix of canola and soybean oils. You can revisit #2 & #3 of this list to read more details about why these oils are not healthy, but basically, soybean oil is too high in omega-6 fatty acids which can lead to inflammation and other diseases. Canola oil is highly processed and treated with chemical deodorizers and solvents.
Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.
3. Avocado Oil: “Avocado oil is extremely high in oleic acid [which protects against cardiovascular disease],” says Hunnes. “It’s even better for you than olive oil: It’s an anti-inflammatory and may help reduce cholesterol.” Avocado oil also has an even higher smoke point than sesame oil (520 degrees Fahrenheit), meaning it’s great for frying foods.
Given CBD’s reputation as a popular, artisanal remedy, one would think that Epidiolex would command a lot of “off label” attention. After all, physicians often prescribe pharmaceuticals off label to treat conditions that were not the actual focus of clinical trials. But the costly price tag for Epidiolex (more than $30,000 annually) precludes off label prescribing as well as affordable access for tens of millions of Americans without health insurance.
Hemp oil can be used for the treatment of minor health ailments and as a dietary supplement for the promotion of general good health. Hemp oil is considered one of the most useful natural supplements for the body due to its ability to provide essential fatty acids to humans that we would not be able to manufacture on our own. However, you should also be aware of potential side effects associated with hemp oil. As such, be sure to speak to a medical professional for more information on hemp oil effects.
Synthetic cannabinoids also pose a significant risk to users because the effects can be much more severe than those produced by marijuana. Some of the compounds in synthetic cannabinoids bind more strongly to brain receptors, which is why the effects could be more powerful and unpredictable. Moreover, synthetic cannabinoid products don’t always list every ingredient on the packaging label, so the effects of the product could be greater or different than expected.
Epilepsy. A specific cannabidiol product (Epidiolex, GW Pharmaceuticals) has been shown to reduce seizures in adults and children with various conditions that are linked with seizures. This product is a prescription drug for treating seizures caused by Dravet syndrome or Lennox-Gastaut syndrome. It has also been shown to reduce seizures in people with tuberous sclerosis complex, Sturge-Weber syndrome, and febrile infection-related epilepsy syndrome (FIRES). But it's not approved for treating these other types of seizures.
There are thousands of unique varieties of hemp. The cultivars used for CBD oil contain significantly higher concentrations of CBD than others. Using these uniquely potent plants, it is possible to extract cannabis oil that contains significant levels of cannabidiol, as well as essential vitamins, minerals, fatty acids, terpenes, flavonoids, and other non-psychoactive cannabinoids.
There’s also the cost factor: Chronic use of CBD oil can be costly and less effective against microbes compared to alternative antimicrobial herbs like Japanese knotweed, cat’s claw, andrographis, garlic, sarsaparilla, and berberine. The bottom line is, CBD oil is a good option for controlling symptoms associated with Lyme disease, fibromyalgia, and other chronic illnesses, but it should be combined with other antimicrobial and immunomodulating herbs for optimal benefit. CBD oil is best used intermittently to treat symptoms of pain or anxiety, or used chronically only until symptoms gradually resolve, and then discontinued.
The primary psychoactive component of Cannabis, delta 9-tetrahydrocannabinol (Δ9-THC), demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors. This activity results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the cannabinoid CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body [5]. Allosteric regulation is achieved through the modulation of receptor activity on a functionally distinct site from the agonist or antagonist binding site which is clinically significant as direct agonists (such as THC) are limited by their psychomimetic effects such as changes to mood, memory, and anxiety[5].
Different cannabis plants are bred to contain different amounts of CBD and/or THC. The plants we know as marijuana are bred specifically to contain CBD and/or THC. However, “the form of the cannabis plant we know as hemp is bred to naturally not contain appreciable amounts of THC, which is the psychoactive compound in the plant people are after when they want a high,” explains Leslie Mendoza Temple, M.D., A.B.O.I.M., medical director of NorthShore University HealthSystem’s Integrative Medicine Program. THC-free hemp plants are referred to as ‘industrial hemp.’

Another concern is about medications with which CBD might interact. This won’t be an issue with most drugs, says Sunil Kumar Aggarwal, M.D., Ph.D., a palliative medicine physician and scientist who studies cannabis and integrates it into his Seattle medical practice. The exceptions are blood thinners, IV antibiotics, and other drugs whose exact dosing is crucial and must be monitored closely, he says. (Of course, if you have a health problem, talk to your doctor before using CBD, and never take it instead of seeing your physician for a serious condition.)
My article is just a summary of what scientists know right now. Knowledge will evolve–that’s a good thing, right? If you want to make a serious decision about what oil is healthiest for you, don’t take my word on it — talk to a doctor or dietitian. A lot of the information about nutrition peddled on the web is from manufacturers or people who work for them, and from fake experts with lots of letters after their names. Read a variety of trustworthy sources and don’t be suckered by sweeping claims. If it sounds too good to be true, it usually is.

Dosage Of Cbd Oil


Synthetic cannabinoids also pose a significant risk to users because the effects can be much more severe than those produced by marijuana. Some of the compounds in synthetic cannabinoids bind more strongly to brain receptors, which is why the effects could be more powerful and unpredictable. Moreover, synthetic cannabinoid products don’t always list every ingredient on the packaging label, so the effects of the product could be greater or different than expected.
I have a dog that was diagnosed with bone cancer. I wasn't going to put an old dog through amputation and chemo, so I opted for comfort care, with the caution from the vet that pain meds would have to be increased until they no longer were able to keep the pain in control and he would have to be euthanized soon. At the recommendation of a friend that I try adding the Hemp Oil to his regimen to see if it helped. Within a day, I started seeing a difference in his behavior, with more alertness and improved movement. He has now been taking one tsp morning and evening and I have actually been able to reduce some of his prescription meds. He is eating well and puttering around with no evidence of pain. The vet expected him to be unable to be kept comfortable and need to be euthanized by now, but the dog didn't get the memo. I expect that the cancer will catch up with him at some point, but he is still enjoying life now and we will keep going until he tells me otherwise. I have told friends about his obvious improvement, and they opted to try it for themselves for various chronic pain conditions that have required heavy-duty prescription pain killers (fentanyl, oxycontin, Ambien) to control. In every incidence, they report significant relief and have been able to reduce or eliminate the prescription drugs. People can sometimes convince themselves something is working by the power of their expectation, even when it isn't (placebo effect), but animals aren't so easily fooled. My only concern is that in the few months I have been purchasing this product the price increased substantially, although it is still reasonable. I just hope it doesn't become so popular that it becomes out of reach for those of us with modest incomes.
This copyrighted, evidence-based medicine resource is provided by Natural Medicines Comprehensive Database Consumer Version. Natural Medicines Comprehensive Database disclaims any responsibility related to consequences of using any product. This monograph should not replace advice from a healthcare professional and should not be used for the diagnosis or treatment of any medical condition.

I use CBD oil for both my own use and for my elderly dog and cat. I have found Kats CBD to be of the highest quality and it has great efficacy for my uses. Customer Service with Kats is also A1. On the one occasion, I had to contact them, I got an immediate response. My last shipment had an issue with the bottle labels, and Kats proactively apologized and gave a free sample of a product as a bonus which was appreciated.
I was diagnosed with vasovagal syncope and in April began have seisures and black outs multiple times a day. I began taking CBD oil on September 1st. Within a week or so I stopped blacking out as often and came to faster. By the end of September Id switched to your product because of the purity. A HUGE IMPROVEMENT Ive been using your 1000 mg bottle for 6 weeks now. Im taking less in the morning and evening. I no longer need a mid day dose. As the weeks go by Ive had no black outs no seisures in several weeks. My energy level has improved my chest pains have gone away. My panic attacks have gone to next to nothing. Ive been able to clean and go out again. Thank you for giving me my quality of life back again. It surely beats taking prescription drugs and dealing with side effects. Only side effects Ive noticed was I stopped sweating profusely everyday and my appetite has decreased and Ive lost a few pounds. YEAH

Cannabinoids are psychoactive compounds with medicinal properties. Tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most studied cannabinoids. CBD has substantially less psychoactive properties than THC. Synthetic cannabinoids (e.g., dronabinol) are closely related to THC. Based on systematic reviews, the evidence published to date indicates that oral cannabis extract is clearly effective, and THC is most likely effective in reducing pain (excluding central neuropathic pain) and spasticity symptoms. They are probably not effective in improving tremor or signs of spasticity.82 There is insufficient evidence for effects on urge incontinence or bladder symptoms.82 Sativex oromucosal spray (unavailable in the US) is probably effective for spasticity symptoms, pain, and urinary frequency, and probably ineffective for signs of spasticity, incontinence episodes, and tremor.82 There is insufficient evidence for these outcomes with inhaled cannabis.82 Prior to recommending this therapy, physicians should counsel patients about the potential legal issues and unwanted side effects.
×