The CBD oil we offer has a couple different applications. You can hold a sublingual dose under the tongue for 30-60 seconds (recommended for fastest absorption), apply the oil topically to your skin (can be applied directly to a problem area or mixed with your favorite moisturizer), or blend the oil in a health-conscious smoothie. We will include further dosing instructions with the product.
WELLGRADE EST. 2017 is exclusively selected hemp oil, made with ‘the feel good plant’ and containing the unique combination of essential fatty acids which have a positive impact on your health in and out. Our product is manufactured in the USA from certified Colorado Hemp, thoroughly tested, CA in a FDA registered facility for quality and consistency. Wonderful product that work wonders!

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^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Like other cannabinoids, CBD readily crosses the blood brain barrier, making it ideal for affecting central nervous system conditions. CBD helps calm the nervous system, reduces inflammation, and is strongly neuroprotective. Not surprisingly, clinical studies evaluating cannabidiol for treatment of anxiety, post traumatic stress disorder (PTSD), seizure disorders (especially childhood seizures), and even schizophrenia have shown remarkable effectiveness.

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MADE IN USA WITH 24/7 SUPPORT: All of our supplements are manufactured, tested and bottled in San Diego, CA in a FDA registered facility for quality and consistency. We also offer email support 24/7 and back every purchase with a 30-day, 100% satisfaction guarantee. If for any reason you are not satisfied with the results simply email us and we can refund you or get you the right product for your needs.
This is true despite the fact that unlike marijuana, hemp contains only trace levels of THC (tetrahydrocannabinol), the chemical component that gives marijuana its euphoric qualities. Instead, hemp is primarily known for its fibers, commonly used to make rope, fabrics, auto parts, industrial materials, and a variety of other products. Hemp is also known for its highly-nutritious seeds (a.k.a. hemp hearts), which have been shown to benefit heart health, skin diseases, and more.

In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [1, 2].
The CBs hold much promise in not only improving stroke but also traumatic and anoxic brain injury outcome. There is a rise in evidence that the endocannabinoids and botanical nonpsychoactive cannabidiol derivatives from the cannabis plant have a multitude of beneficial effects, particularly with ischemic stroke. Animal models of stroke have shown cannabidiol increases cerebral blood flow (CBF) mediated by 5-hydroxytryptamine (serotonin) receptor 1A (5HT1A) receptors and induces vasorelaxation [12].

To Nancy G…. I’m not an oil expert, but Oleumm8 makes part of its health claim based on a lower ratio of omega-6 to omega-3 fatty acids, compared with the average American diet. Some studies suggest that lowering the ratio of O6 to O3 could be healthy. But, again, from a scientific point of view, this is still an unproven hypothesis. Many nutrition authorities suggest raising your omega-3 intake by consuming two or more fish meals a week.
Nutrition: One tablespoon has 130 calories and .5g of saturated fat—per Thrive Culinary Algae Oil. That’s the lowest percentage of saturated fats among any other cooking oil. To put things in perspective, algae oil is comprised of 4 percent saturated fat, while olive oil contains 14, canola 7, and coconut 87. Conversely, algae oil also contains the highest level of monounsaturated (good) fats, boasting 90 percent monounsaturated fat, while olive oil has 74, canola 63, and coconut just 6.
In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates 5-HT1A/2A/3A serotonergic and TRPV1–2 vanilloid receptors, antagonizes alpha-1 adrenergic and µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) [1, 2].
I have numerous auto-immune diseases, including Fibromyalgia! Been ill for about 35 years. Started taking hemp oil/cbd oil about 2 weeks ago. Where I purchased it lady told me to put and hold under my tongue for 10 seconds then swallow. Didn’t see much change, then researched and found out that I should have been keeping under tongue for 90 seconds. I did this and have seen lots of improvement! Research showed that when u hold it under tongue for that amount of time, it bypasses digestive system and goes straight to your bloodstream to brain! Just for the record, it showed that this way of consuming the oil is the best way for best results! Iv noticed that I am forgetting to take my pain meds and am not needing them like usual! I’m sleeping better, and am more relaxed! This is my experience and thought it might help someone else like me, with so many issues! Only been taking for 2 weeks! Remember knowledge is power, so do your research before taking to get best results!💜
Refined hempseed oil is clear and colorless, with little flavor and lacks natural vitamins and antioxidants. Refined hempseed oil is primarily used in body care products. Industrial hempseed oil is used in lubricants, paints, inks, fuel, and plastics. Hempseed oil is used in the production of soaps, shampoos and detergents. The oil has a 3:1 ratio of omega-6 to omega-3 essential fatty acids.[3] It may also be used as a feedstock for the large-scale production of biodiesel.[4]
I have a dog that was diagnosed with bone cancer. I wasn't going to put an old dog through amputation and chemo, so I opted for comfort care, with the caution from the vet that pain meds would have to be increased until they no longer were able to keep the pain in control and he would have to be euthanized soon. At the recommendation of a friend that I try adding the Hemp Oil to his regimen to see if it helped. Within a day, I started seeing a difference in his behavior, with more alertness and improved movement. He has now been taking one tsp morning and evening and I have actually been able to reduce some of his prescription meds. He is eating well and puttering around with no evidence of pain. The vet expected him to be unable to be kept comfortable and need to be euthanized by now, but the dog didn't get the memo. I expect that the cancer will catch up with him at some point, but he is still enjoying life now and we will keep going until he tells me otherwise. I have told friends about his obvious improvement, and they opted to try it for themselves for various chronic pain conditions that have required heavy-duty prescription pain killers (fentanyl, oxycontin, Ambien) to control. In every incidence, they report significant relief and have been able to reduce or eliminate the prescription drugs. People can sometimes convince themselves something is working by the power of their expectation, even when it isn't (placebo effect), but animals aren't so easily fooled. My only concern is that in the few months I have been purchasing this product the price increased substantially, although it is still reasonable. I just hope it doesn't become so popular that it becomes out of reach for those of us with modest incomes. 

CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
Unlike the oils listed above, coconut oil is actually a saturated fat. And though saturated fats are commonly suggested to use with caution, research has explored coconut oil’s beneficial use. While the studies were small in size, data suggests coconut oil may lead to small weight loss. Coconut oil contains medium-chain fatty acids or medium-chain triglycerides (also known as MCTs) that are thought to not become stored within fat cells like long-chain fatty acids
Soy is something that is best avoided or at least reduced in consumption unless it is fermented (like tempeh, natto or fermented soy sauce). Soy is high in phytic acid and trypsin inhibitors which means that it blocks the absorption of many vitamins, minerals and proteins. It also contains phytoestrogens that can mimic estrogen in the body and disrupt normal hormone function which could possibly lead to increased cancer risk.
The 3000 tincture has been very helpful for me with: chronic & acute wide spread pain, headaches, anxiety, sleep, nausea, & allergies....not a complete cure, but a tremendous help with all of these, & with absolutely no side effects (& I am extremely susceptible to any side effects from meds & some supplements)....very happy to have found this product.

Still, vegetable oils are refined and processed, which means they not only lack flavor, but also nutrients, Howard says. “Vegetable oil is guaranteed to be highly processed. It’s called ‘vegetable’ so that the manufacturers can substitute whatever commodity oil they want—soy, corn, cottonseed, canola—without having to print a new label,” she says. “Processed oils have been pushed past their heat tolerance and have become rancid in the processing.” Some of these oils, especially palm, are associated with more degradation of land for production, Howard says.
^ Hayakawa K, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M (March 2007). "Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance". Neuropharmacology. 52 (4): 1079–87. doi:10.1016/j.neuropharm.2006.11.005. PMID 17320118.
This product was recommended for me by a friend and I couldnt be happier that we talked about this. Ive had very minor issues with anxiety from work or personal life. By taking this in the morning it really has helped me with those feelings and allowed me to enjoy my day and focus more. Its had a significant affect on my personal life and work because of it. Will be recommending to all my friends who have similar issues.

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CBD (cannabidiol) oil is a popular product for everything from pain control to promoting sleep. However, with the rise of CBD comes the concern about failing a drug test due to detection of CBD oil. News stories are emerging across the country involving famous sports players, employees of companies, and others who have gotten positive drug screening results for the presence of THC—the psychoactive component of marijuana—even though CBD oil is said to be THC-free. 

By popular demand, we have also begun to carry several, high quality CBD pet products as well. For general purpose applications, we carry several, tasty tincture and oral spray options that are highly effective. Likewise, Pharma CBD capsules provide CBD purity via capsular ingestion. In addition, we have partnered with Therabis, the quality CBD maker of “Stop the Itch” and “Calm and Quiet”, the pet lovers’ ultimate go-to’s. Find these products by browsing our exclusive online inventory.
By popular demand, we have also begun to carry several, high quality CBD pet products as well. For general purpose applications, we carry several, tasty tincture and oral spray options that are highly effective. Likewise, Pharma CBD capsules provide CBD purity via capsular ingestion. In addition, we have partnered with Therabis, the quality CBD maker of “Stop the Itch” and “Calm and Quiet”, the pet lovers’ ultimate go-to’s. Find these products by browsing our exclusive online inventory.

Peanut oil is one of the more flavorful oils out there. Meaning, you should probably only use it if you want your food to be peanut flavored. Sasson recommends adding it to peanut butter cookies, or using it to sautée stir-frys. It also has a high smoke point (450 degrees F) so you can even use it to fry foods like tempura. Like vegetable and canola oil, it is also chemically processed and low in saturated fat.
Scott Shannon, M.D., assistant clinical professor at the University of Colorado, recently sifted through patient charts from his four-doctor practice to document CBD’s effects on anxiety. His study, as yet unpublished, found “a fairly rapid decrease in anxiety scores that appears to persist for months,” he says. But he says he can’t discount a placebo effect, especially since “there’s a lot of hype right now.”

I did an analysis of 10 diffirent CBD oils and Medterras 3000mg bottle is the most cost effective per mg. Their product also appears the safest with where they source their materials and how they conduct their business. There were no issues with the ordering process and I received my product in a timely fashion as well. There is almost no taste to the oil and I take 25 ml (25 mg) twice daily with excellent results. I finely feel calm and sleep well. I am also able to focus better and get more done each day, which was an unexpected bonus. I was very sceptical about CBD at first. I have tried everything for my anxiety, and although some of the traditional drugs work, their side effects negate any benefits. I was feeling very frustrated and hopeless and ordered the CBD out of desperation. Im glad I took the chance. Well, it wasnt really a chance; I read every research article I could get my hands on and was swayed by the emerging data. I guess it was more of a leap of faith in a product that had such high claims and no healthcare gatekeepers. I have had no side effects though. The only negative is the cost.
I just started taking CBD oil , I am on my 2nd Hip replacement surgery due to device failures looking at a 3rd surgery. Has you can imagine the pain, stress and anxiety levels are off the charts. Especially at an otherwise healthy 54 yr women. So i understand from reading posts its best to take it under the tongue. I am taking 1-2 ml a day. I can tell some difference,is your recommended dosage. I am using for pain , stress and sleep. I appreciate your feedback.
Yet another benefit of essential fatty acids is mood health. Several studies have shown that Omega 3 supplementation can improve symptoms in bipolar disorder. Others have found improvements in. This could be because essential fatty acids are critical to maintaining brain function.  Endocannabinoids are also essential for mood. The endocannabinoid system regulates the release of neurotransmitters, some of which play major roles in conditions like depression and anxiety. As mentioned previously, endocannabinoids are made from fat. Consuming extra essential fatty acids gives your body the ability to produce these lipids.
I don't know about you, but I grew up thinking canola oil was one step away from propane—AKA, really friggin bad for you. Shaw begs to differ. She says people often think of it as unhealthy because they associate it with fried food. And though yes, canola oil's high smoke point (400 degrees F) and neutral flavor makes it an excellent vehicle for frying, it isn't actually all that bad for you on its own. Much like most of the other healthy oils on this list, it's low in saturated fats, and can be used for roasting, frying, and baking. Because it has a neutral taste that doesn't do much for your food in the flavor department, cooks don't usually recommend using it for sautéing. The reason it has a high smoke point is because it is chemically processed, but that doesn’t have much of an effect on its health qualities.
Rosenberg, Tsien, Whalley, and Devinsky (2015) have recently reviewed the role of cannabinoids in epilepsy; highlighting proconvulsive effects (e.g., THC) and anticonvulsive effects (e.g., cannabidiol). The mechanisms of action of cannabidiol in epilepsy have also been recently reviewed (Reddy & Golub, 2016). Much work with SCB in epilepsy has focused on WIN55,212-2. WIN55,212-22 potentiated the effects of four antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, and valproate) in mice (Luszczki et al., 2011). However, the authors also caution that impairment of motor coordination, long-term memory, and a reduction of skeletal muscular strength was also seen with these combination treatments. The same group found WIN 55,212-2 in combination with lamotrigine, pregabalin, and topiramate and second- and third-generation anticonvulsants gabapentin, levetiracetam but not lacosamide, oxcarbazepine, pregabalin, and tiagabine to potentiate anticonvulsant effects in mice (Florek-Luszczki et al., 2015; Luszczki, Wlaz, Karwan, Florek-Luszczki, & Czuczwar, 2013).

Excessive amounts of omega-6 polyunsaturated fatty acids (PUFA) and a very high omega-6/omega-3 ratio, as is found in today’s Western diets, promote the pathogenesis of many diseases, including cardiovascular disease, cancer, and inflammatory and autoimmune diseases, whereas increased levels of omega-3 PUFA (a lower omega-6/omega-3 ratio), exert suppressive effects.”


Yet another benefit of essential fatty acids is mood health. Several studies have shown that Omega 3 supplementation can improve symptoms in bipolar disorder. Others have found improvements in. This could be because essential fatty acids are critical to maintaining brain function.  Endocannabinoids are also essential for mood. The endocannabinoid system regulates the release of neurotransmitters, some of which play major roles in conditions like depression and anxiety. As mentioned previously, endocannabinoids are made from fat. Consuming extra essential fatty acids gives your body the ability to produce these lipids.
If you’re looking into CBD oil for sale, our NEW high potency full spectrum CBD oil is exactly what your body ordered. This hemp oil comes more dominant and stronger than our regular CBD oil online products and provides even faster relief. This high volume boost of potency is available in 500 mg and 1000 mg of cannabinoids, and you will quickly realize why sometimes less is more. Supply your overall mental and physical health with a CBD upgrade. This CBD oil is the same great quality you have come to expect from Kats Botanicals, but with an extra kick. Our high potency full spectrum hemp oil is made with pesticide free, non-GMO industrial hemp oil, extracted from the mature stalks and stems of the hemp plant.

There are many hair health benefits of hemp oil as well. Many non-commercial and herbal hair products like shampoos, hair oils, conditioners, etc. are made by using hemp oil. Like the skin care, massages with hemp oil products can improve blood circulation in the head and the brain. Washing hair with hemp oil shampoos and conditioners, can thicken the hair texture and keep the scalp away from dandruff. Thus hemp oil is very beneficial for your hair care as well. Loss of hair is also reduced by using them and scalp infections and problems are kept away.
Along with its better-known counterpart, THC (delta-9-tetrahydrocannabinol, the chemical that produces the marijuana high), CBD is one of more than 400 compounds found in the oils of cannabis plant species, which include marijuana and hemp. Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, Ph.D., director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
It is important to note that omega-3 fats are considered an essential nutrient, meaning that you can only obtain them from the foods or supplements you consume. They are found in many types of food but most prominently in fish and seafood. Because they aren't synthesized by the body like other fats, you need to actively search them out in order to ensure you have ample quantities in your diet.
When the title of Best CBD Hemp Oil was up for grabs, it’s little wonder the renowned Charlotte’s Web Hemp Extract from CW Hemp took the crown with room to spare. This potent and clean hemp oil extract has earned itself a remarkable reputation over the years, and the handy and discreet tincture is the ideal way to sample its soothing benefits for yourself.

Condensed CBD oil can be taken as a thick paste, but this is the least pleasant option. More commonly, the CBD oil is mixed with a carrier oil, such as hemp oil or coconut oil, to a specific concentration of CBD. The distinctive taste — which comes from the terpenes and not the cannabinoids — is often masked with chocolate, mint, or other flavorings. It typically comes in a small bottle with a dropper to administer the oil mixture. 

Well I have come to the conclusion that Amazon is riddled with sellers trying to capitalize on the CBD frenzy by promoting hemp oil for "pain relief" or "anxiety" , etc... because keep in mind they are not outright saying it contains CBD but they are certainly promoting CBD-like-capabilities. They are not lying but they are also not being clear. You can decide for yourself if you feel that is on purpose and misleading.

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The main points are to use cooking oils in moderation, Lichtenstein said. The government's U.S. Dietary Guidelines recommend that Americans include a small amount of oils in their diets every day to supply essential fatty acids, because the body can't make these acids and thus must get them from food. There are two such fatty acids, and both are polyunsaturated fatty acids: linoleic acid and alpha-linolenic acid.

I placed my first order well over a month ago, but wanted to wait until I could give a more accurate review of Medterras CBD tincture. Ive dealt with the pain of fibromyalgia for many years, and never wanted to take the harsh prescription drugs usually associated with the condition (the side effects seem worse than living with the condition itself!). I did a great deal of research on hemp CBD and thought Id at least give it a try. I am both surprised and pleased to report that I have found a significant difference since taking CBD. Obviously, I cant say that it will work for everyone and every condition, but I will say that at least in my case, it has improved the quality of my body movement significantly. Certainly worth a try if you are at all hesitant.

I have been recently diagnosed with a rare brain disease. This product helps with the debilitating headaches and the extreme nausea. My geneticist recommended this product to me. My doctor is on the cutting edge of genetic research and is highly regarded and published in several scientific journals. This product is effective and the best part is the fact that there are no side effects like other medications.

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